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Although inconsistent data is available [84,85], most studies subsequently confirmed the in vivo benefit of GLP-1 RAs on fatty liver disease [50,56,57,58,61,71,74,76,77,81,84,85,86,87,88,89,90] (Table 3)

Semaglutide, known as Ozempic and Rybelsus, offers more flexibility with once-weekly injections and a once-daily oral formulation, making it a more convenient option for many patients

[16] GLP-1 endogenous in humans [16] glucagon endogenous in humans [16] oxyntomodulin amycretin/ zenagamtide UBT251 exendin-4 [16] [17] exenatide lixisenatide [16] albiglutide beinaglutide dulaglutide efpeglenatide langlenatide liraglutide [16] polyethylene glycol/PEG- loxenatide semaglutide taspoglutide ecnoglutide utreglutide glepaglutide apraglutide maridebart cafraglutide tirzepatide pegapamodutide mazdutide survodutide bamadutide pemvidutide cotadutide retatrutide Lithium chloride Cinchonine grutalumab dapiglutide DA1726 GX-G6 GZR18 HRS9531/ KAI-9531/ Ribupatide PB718 RAY1225 VCT220 VK2735 BLX7006 supaglutide/ efsubaglutide ASC30 HRS7535 Danuglipron Aleniglipron Lotiglipron Orforglipron (non peptide partial agonist) [18] Conveglipron Elecoglipron/ AZD 5004/ ECC 5004 CT-996 CT-388/ Enicepatide CT-868 HEC88473 HS-10535 UBT251 efinopegdutide efocipegtrutide Berobenatide NNC9204-1706 TG103 YP05002/YP-05002 Positive Negative Clinical significance [edit] GLP-1 receptor agonists are a class of medications that mimic the actions of the endogenous incretin hormone GLP-1, and are used in type 2 diabetes and obesity

NAFLD, non-alcoholic fatty liver disease

retail costs, making GLP-1 therapy more accessible even without insurance coverage

Theyve existed for quite some time for a variety of pharmaceuticals