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Group one included patients with moderate PAD who were started on GLP-1 RAs, and group two included patients with moderate PAD who were not started on GLP-1 RAs. At one year, patients with moderate PAD who were started on GLP-1 RAs had fewer major adverse limb events (MALE) (0.8% vs 1.5%), major adverse cardiac events (MACE) (25.4% vs 29.3%), and decreased risk of hospitalizations (17.9 vs 26.8%)

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The FDA recently ordered producers to wind down the compounding of these drugs on the grounds that there were no longer the shortages of the originator drugs that had justified temporary concessions to ensure patients had access to the medications