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Consider maintaining a symptom diary to note: The frequency and consistency of stools Dietary choices and any correlations with symptoms Any accompanying symptoms, such as nausea or abdominal pain By documenting your experiences, you can better understand what works for you and share this information with your healthcare provider for tailored advice

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The numbers reported on 21 May 2026: 4 mg dose: 17.6% average body weight loss at 80 weeks 9 mg dose: 23.7% average body weight loss at 80 weeks 12 mg dose: 25.0% average body weight loss at 80 weeks rising to 28.3% on the efficacy estimand Placebo: 3.9% average body weight loss at 80 weeks And then the extension cohort 532 participants with starting BMI 35, escalated to their maximum tolerated dose for another 24 weeks lost an average of 30.3% of their body weight at 104 weeks