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For subcutaneous semaglutide, we recommend starting 0.5 mg once weekly for 4 weeks before advancing to 1 mg once weekly, depending on tolerability and clinical necessity

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[DOI] [PubMed] [Google Scholar] 100.Iorga RA, et al

Indirect comparison across trials suggests tirzepatide produces greater weight loss at currently approved doses

Long-term plasticity of hippocampal interneurons during in vivo memory processes