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2 Wegovy is the only FDA-approved weight management medicine to reduce the risk of major adverse cardiovascular events, including heart attack, stroke and cardiovascular death in people with obesity and known heart disease

In pancreatic -cells [58] and ischaemic coronary vascular cells [59], activating GLP-1R promoted mitochondrial respiration, while in astrocytes, GLP-1R activation suppressed mitochondrial oxidative phosphorylation stimulated by -amyloid peptides [60]

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Physicians are also able to prescribe Mounjaro and Ozempic off-label. That means these drugs are approved to treat diabetes, but because the active ingredient (tirzepatide and semaglutide, respectively) is the same, they could be prescribed to people who need it for weight loss who dont have diabetes