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The FDA approach to GLP-1 compounding will set precedents that affect access to peptide therapy across many categories

The bodyweight signal was the most consistent finding across studies, whereas glycaemic and CGM outcomes were more variable and more vulnerable to confounding

Tirzepatide demonstrates approximately 5-fold selectivity for GIP over GLP-1 receptors, making it a GIP-dominant dual agonist

Referral to endocrinology may be appropriate for patients with complex diabetes requiring multiple medication adjustments, those with a history of severe hypoglycemia, or individuals with diabetic complications requiring specialized management

Patients with type 2 diabetes who are about to begin, or who have recently begun, taking a GLP-1 drug should have a baseline dilated eye examination to determine their level of DR