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Clinical trials for glycemic control in moderate-to-severe CKD: AWARD-7, LIRA-RENAL

Chronic treatment with the co-agonist also improved glucose tolerance and insulin secretion in cynomolgus monkeys and humans [91]

The analysis of subgroups based on the results of 2 randomized controlled trials and supporting data from 4 observational studies suggest that GLP-1RAs can reduce alcohol consumption in some categories of patients [94]
Further research in developing alternatives toward Gliptins especially for long-acting medications would be an interesting new approach to improve lifestyle of patients

In a Phase 2b study in people with type 2 diabetes and obesity over 54 weeks, treatment with cotadutide at doses of 100-300 g daily improved some non-invasive markers of NAFLD such as transaminase levels, the FIB-4 index, fatty liver disease fibrosis score (NFS) and fatty liver index (FLI) but fatty liver disease was not assessed directly with liver biopsy