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In cells with GPX4 knockdown, it was confirmed that mitochondrial GPX4 rather than cytoplasmic GPX4 was able to make cells more resistant to ferroptosis

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In addition, secondary analyses were performed with 1:1 nearest-neighbor propensity score matching and an exact match for baseline variables differing by 20% between cohorts for each study population

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This is why resistance training and high-protein diets are strongly recommended as part of any medical weight loss program