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2017 Oct 17;318(15):1460-1470

This is especially true for women in midlife, when hormonal changes can make plateaus even more stubborn

For women with BMI over 30 (obesity), gain 11 to 20 pounds

This is particularly important if you have other medical conditions, take multiple medications, or have previously experienced adverse drug reactions
Although extremely costly and time-consuming, these outcome trials have, nevertheless, provided us with extremely valuable information about the natural history of the diseases, drug safety and the influence of the drugs on the disease progression