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A 2025 systematic review and meta-analysis in Reviews in Endocrine and Metabolic Disorders found that tirzepatide (the active ingredient in Mounjaro and Zepbound) reduced hsCRP by approximately 33% and IL-6 by approximately 18% compared to placebo across patients with and without diabetes. A growing body of research suggests this effect occurs through direct action on the NF-B pathway, a master switch of inflammation
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Hepatology 2006;43:173-81.ArticlePubMedPMC 37
These drugs are divided into: incretinmimetics, derived from exendin-4 (a peptide obtained from the saliva of the Gila monster [Heloderma suspectum])
The pharmacokinetic differences between these drugs lead to important differences in their pharmacodynamic profiles
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