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We also confirmed the effect of GLP-1R on microglial activation in lipopolysaccharide-treated BV-2 microglia

In a statement following the EMA PRACs decision, Alison Cave, chief safety officer at the MHRA, said: We are currently reviewing safety data on the risk of suicidal thoughts and thoughts of self-harm associated with medicines known as GLP-1 receptor agonists, used for treating both type 2 diabetes and weight loss

After five half-lives (25 days), approximately 3.1% of the last dose remains in circulation

doi: 10.30699/jambs.31.149.514

Both medicines are approved in China for weight management and Type II diabetes and belong to the GLP-1 receptor agonist class