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A spokesperson for Eli Lilly, which produces Zepbound and Mounjaro, told The Independent that Zepbound and Mounjaro autoinjectors and Zepbound vials are approved for single-use onlydose-splitting or microdosing is not contemplated by the FDA-label and may pose patient safety risks. Novo Nordisk, which produces Ozempic and Wegovy, told The Independent the company "[does] not condone the misuse of our products." The company noted it is concerned about non-FDA approved knock-off versions of semaglutide and sources spreading misinformation about GLP-1s to the public. The FDA warns that using unapproved versions of GLP-1 drugs can be risky for patients. This story was updated on September 4, 2025 to include responses from Eli Lilly and Novo Nordisk Join our commenting forum Join thought-provoking conversations, follow other Independent readers and see their replies Comments

However, this varies based on individual goals, health needs, severity of condition, and other factors

The key takeaway: portion size matters

NAD(+) analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

Wegovy and Other Injectable Options For those interested in injections, Wegovy offers significant weight loss, proven by its effectiveness in clinical trials, where patients saw a 14.9% reduction in body weight

Given the results, Bonaca suspects that semaglutide may be a useful treatment for all patients with peripheral artery disease, as the data suggests the drug has anti-inflammatory properties
