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Description
Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise
In a multicenter, randomized, double-blind trial of liraglutide including 251 adolescents, liraglutide with lifestyle therapy led to significant BMI reduction compared to placebo after 56 weeks of treatment
7:e159863
10.1111/1755-5922.12317 15 GargV.VermaS.ConnellyK
Rev Endocr Metab Disord 2022
The dual mechanism is designed to mimic the complementary metabolic effects of diet and exercise: GLP-1 receptor activation reduces appetite and enhances insulin secretion, while glucagon receptor activation increases energy expenditure and promotes hepatic fat oxidation
