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In addition, some putative effects of GLP-1RAs on cognitive and mental health symptoms may not require direct activity in the CNS, but rather be mediated by the actions that these medications express in the periphery across immune, endocrinemetabolic and gutbrain axis mechanisms (Fig
Glucagon-like peptide-1 acutely affects renal blood flow and urinary flow rate in spontaneously hypertensive rats despite significantly reduced renal expression of GLP-1 receptors
Matthews JE, Stewart MW, De Boever EH, Dobbins RL, Hodge RJ, Walker SE, et al
Clinical data also indicate beneficial molecular effects of GLP-1 RAs, despite their potential to reduce muscle mass
The results seem to be better with once-weekly administered GLP-1 RAs compared to those requiring once-daily injections [26,27,28]
