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Studies have shown that GLP-1 release is influenced by: Dietary fiber , particularly fermentable fibers Protein intake , especially when evenly distributed across meals Healthy fats , which slow digestion and enhance satiety signaling Gut microbiome activity , which plays a direct role in GLP-1 secretion These factors help explain why whole-food diets rich in fiber and protein are consistently associated with better appetite regulation and metabolic health

doi: 10.1111/dom.13979

If a patient plans pregnancy or becomes pregnant, Rybelsus should be discontinued at least two months before a planned conception due to the long half-life of semaglutide
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That gives the body a steadier, stronger version of a signal it already understands to slow digestion, feel full sooner and quiet the urge to keep eating
