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PCOS phenotypes characterized by insulin resistance, hyperinsulinemia, and obesity may benefit most from Retatrutide

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Key Takeaways Compound: Retatrutide (6.0-day half-life, GLP-1/GIP/glucagon triple agonist) Protocol length: 12 weeks covering 3 dosing phases Steady state: Reached in approximately 4.3 weeks at each dose level Transition period: Expect 4-5 weeks for levels to stabilize after a dose change Investigational Drug: Retatrutide is not FDA-approved and is currently in Phase 3 clinical trials