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Sequencing and Combination Use of SGLT2is and GLP-1 RAs There was agreement that sequential or upfront combination therapy with SGLT2is and GLP-1 RAs is appropriate for individuals with ongoing kidney progression, high cardiovascular risk or suboptimal metabolic control

Pharmaceutical versions amplify these effects, reducing appetite and promoting satiety, or a feeling of fullness

Each increase may temporarily intensify side effects before tolerance develops again

Although they are not directly FDA-approved, they provide a science-backed alternative when prescribed by a qualified doctor
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