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In the first nine months of 2025, Mounjaro and Zepbound generated combined sales of $24.8 billion for the company (accounting for 54% of Eli Lillys revenue)

Current Wegovy labeling reports constipation among common adverse reactions, with 24% of adults receiving Wegovy 2.4 mg injection reporting it in the weight-reduction trials summarized in the label

As these receptors are blocked by the PTDs, they may become insensitive (for example, leptin resistance), inducing hypermetric hormonal responses with resultant obesity and metabolic dysregulation

Our integrated approach has led to more than 96% of Oshi patients on GLP-1s reporting improvement and control over their symptoms within six months of starting care, which led to better reported quality of life and increased medication adherence

doi: 10.2337/dc08-0029

Evaluating Biometric Trend Drivers: How to reflect medical breakthroughs and other drivers in forward-looking assumptions explores the practicalities of how to maintain an up-to-date view on emerging drivers such as AOMs and provides a framework for incorporating insured impacts into insured improvement bases