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Human Evidence 1

At the same time, the data imply that a medicinal chemistry campaign focusing on engineering pharmacokinetically optimized GLP-1MK-801 conjugates might give rise to drugs that could outperform the current incretin-based treatments for obesity, such as semaglutide and tirzepatide

If you are in a dose escalation phase with persistent nausea, increase your baseline by 20-30% even if you are not actively vomiting, because reduced food and fluid intake from nausea creates a slow dehydration that builds over days

doi: 10.1002/14651858.CD006739.pub2

Sarah Fishman, M.D., a professor of medicine, endocrinology, diabetes, and bone disease at Icahn School of Medicine at Mount Sinai in New York City

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