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Additional considerations include diabetic retinopathy status (semaglutide may worsen retinopathy in some patients with pre-existing disease, particularly with rapid A1c improvement), history of pancreatitis (use GLP-1 agents with caution), and upcoming surgical procedures (discuss with your surgical/anesthesia team due to effects on gastric emptying)

Several underlying issues can cause symptoms like fatigue, anxiety, mood problems, and insomnia, and its important to suss out any medical causes

For weekly medications, the timing has less impact on side effects due to their steady-state pharmacokinetics

How is it stored

While they are very effective in treating diabetes and assisting with weight loss, there is a great deal of concern regarding potential adverse effects, including stomach paralysis

Effect of semaglutide on physical function, body composition, and biomarkers of aging in older adults with overweight and insulin resistance: protocol for an open-labeled randomized controlled trial