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Glucagon-like peptide-1 receptor agonist (GLP-1RAs) and more recently Twin-Cretins (GLP+GIP) are frequently used for patients with diabetes and associated obesity

GLP-1 receptor agonists (semaglutide, liraglutide, tirzepatide) act on the brain as well as the gut, and a 2026 real-world cohort study from Kamel-Abusalha et a

These patients face a critical problem: they're losing 25-40% muscle mass alongside fat loss, experiencing seve

Contemporary recommendations advise very low targets for patients at highest risk.

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