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Cardiovascular Outcomes Trials of Incretin-Based Therapies
Tirzepatide, the newest medication for type 2 diabetes: A review of the literature and implications for clinical practice
The cleaving action of DPP4 on these hormones attenuates their activity and potentially contributes to impaired insulin secretion

Solerte SB, DAddio F, Trevisan R, et al
Powering the study for those end points would have required a large increase in number of participants

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