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Overall, although a net beneficial effect on several cardiometabolic variables was maintained 1 year after semaglutide withdrawal, greater benefits were seen during the treatment period, supporting the need for continued treatment

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Randomized double-blinded placebo-controlled withdrawal studies were performed in both semaglutide and tirzepatide with crossover to placebo at 20 weeks and 36 weeks, respectively [242,243]

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