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A subset of patients with severe obesity who kept taking retatrutide in a study extension continued to slim down, losing up to an average of 85 pounds, or 30% of their body weight, at two years, the company said in a statement detailing the Phase 3 trial results

Let's look at some of the reasons why exercise, primarily via resistance training, is crucial for losing the most weight while on GLP-1 and reducing weight regain when off of it

But, like many medications, it comes with potential side effects that users must be aware of

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Many insurers have imposed requirements such as prior authorization or step therapy, which mandates that people try less expensive drugs first

This sequencing keeps side effects manageable and makes it far easier to identify which approach is causing any specific symptom