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Patients with certain genetic variants show stronger appetite rebound and benefit from continuous low-dose therapy, while others may succeed with structured breaks or lower maintenance doses

Ethics declarations Ethics approval and consent to participate The protocol was approved by local ethics committees and institutional review boards at each participating center

Moreover, it makes the case that obesity (and its metabolic consequences) is the underpinning of HFpEF

Further optimization led to once-weekly administration instead of daily administration, longer-lasting presence in plasma (blood), superior target outcomes (i.e