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We conducted rigorous target trial emulation, performed sensitivity analyses using negative control outcomes, quantified E -values to assess the potential impact of unmeasured confounding, and validated previous findings of the association of semaglutide or tirzepatide with increased risk of NAION

Therefore, a role for reduced interdigestive motility induced by GLP-1RA treatment in the increased risk of retained gastric content remains a hypothesis to be further substantiated by dedicated studies

In addition, the redox-sensitive probe DHE were employed to test if the protective effect of GLP-1 on HUVECs is associated with a decreased vascular pro-oxidant response

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Serotonin syndrome occurs when serotonergic activity in the nervous system becomes excessive, typically from combining two strongly serotonergic drugs