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Oral semaglutide showed cardiovascular safety profile, with significant reduced risk of death from cardiovascular events

The review urges nurse practitioners to balance expanding clinical promise with careful prescribing, patient education, monitoring, access advocacy, and vigilance for gastrointestinal, endocrine, pregnancy-related, and rare serious risks.

GLP-1 analogs are widely used to treat patients with type 2 diabetes in recent years

Several multi-targeting agonists at GIPR, GLP-1R or GCGR, developed to maximize metabolic benefits with reduced side-effects, are in clinical trials to treat type 2 diabetes and obesity

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