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glp-1 agonists diabetes New Guidelines for Type 2 in 2025 Mechanisms of action of GLP-1RA.
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Masmiquel L, Leiter LA, Vidal J et al

Particularly where obesity rather than diabetes is the main target
GLP1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress

Manza, P

This data supports a treatment paradigm in which patients could initiate treatment with potent injectable agents for maximal initial weight loss and then transition to oral orforglipron for long-term maintenance, reducing the burden of chronic injection therapy

This update was prepared for World Obesity Day 2026
