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Through a reduction in extracellular glutamate and an increase in pro-survival signaling, Hernndez et al

How Rapid Weight Loss Can Strain Your Spine and Joints When the body loses weight quicklyespecially 5 to 10 pounds per month during GLP-1 therapythe spine, knees, and hips adjust to a new load distribution

From there, if youre still not seeing a change, it could be worth reviewing your medications with your doctorboth your GLP-1 and any others you may be taking

1 Several health conditions, including diabetes and Polycystic Ovarian Syndrome (PCOS), can affect the amount of GLP-1 released in the body or weaken the sensitivity of the receptors it binds to, leading to insulin resistance

For example, INT-777 and MN6, TGR5 selective agonists, stimulated GLP-1 secretion and improved insulin sensitivity in diet-induced obesity (DIO) mice [180, 181]