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This effect is separate from the alterations in body mass index that accompany the normal aging process

More than ever, its management demands a multidisciplinary approach, not only to ensure effective treatment but also to prevent long-term complications and support overall quality of life [16]

And for those whose weight resistance is compounded by hormonal shifts low testosterone in men or perimenopausal changes in women combining GLP-1 treatment with hormone replacement therapy for men or hormone replacement therapy for women can address both drivers at once instead of just one

PubMed, Foer, Dinah, et al

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Additionally, changes in insulin sensitivity associated with weight loss and improved glycaemic control can alter the hormonal milieu, particularly in women with insulin resistance