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Phase 2 obesity trials showed average weight loss of 24.2% at 48 weeks at the 12mg dose, with 100% of participants achieving 5% weight loss, 93% achieving 10%, and 83% achieving 15%

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Traditionally used in Chinese and Ayurvedic medicine for centuries, berberine has gained considerable attention in recent years as a dietary supplement marketed for metabolic health, particularly blood glucose control and weight management

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Study participants injected themselves weekly with semaglutide, beginning with a dose of 0.25 mg and increasing to 1 mg at week 4, which is the dose prescribed for diabetes, Lake said