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As a dual GIP and GLP-1 receptor agonist, it uniquely targets two major hormonal pathways that regulate appetite, blood sugar, and fat storage

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Most tirzepatide side effects especially GI events like nausea, diarrhea, and constipation peak in the first 1 to 2 weeks of starting and after each dose increase

It increases sex hormone-binding globulin in some contexts while paradoxically reducing it in others, creating unpredictable fluctuations in bioavailable testosterone

The Phase 2b IMPACT trial demonstrated MASH resolution without worsening fibrosis, with weight losses of 4-6% over 24 weeks at current doses

Weighing yourself daily in the first week produces anxiety, not data
