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As a dual GIP and GLP-1 receptor agonist, it uniquely targets two major hormonal pathways that regulate appetite, blood sugar, and fat storage

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Most tirzepatide side effects especially GI events like nausea, diarrhea, and constipation peak in the first 1 to 2 weeks of starting and after each dose increase

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It increases sex hormone-binding globulin in some contexts while paradoxically reducing it in others, creating unpredictable fluctuations in bioavailable testosterone

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The Phase 2b IMPACT trial demonstrated MASH resolution without worsening fibrosis, with weight losses of 4-6% over 24 weeks at current doses

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