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This circadian rhythm is regulated by food intake..

On the flipside, there are challenges: for example, concerns about cost to healthcare systems and equity of access for patients with the greatest unmet needs, or the possible impact on Medtech currently used by patients suffering from obesity related conditions for example knee replacements for overweight patients with eroded joints or CPAP machines for sleep apnoea, a complication of obesity

These findings highlight the importance of targeted therapeutic strategies based on HF phenotypes

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