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Why does prolonged use of GLP-1 receptor agonists (GLP-1RAs) increase the risk of gallstones and inflammation of the liver, gallbladder, and pancreas

Discover how GLP-1 medications like Ozempic work within your body to control blood sugar and support weight loss through a multi-organ approach

New phase 2 data demonstrate even greater weight loss for an investigational triple agonist, retatrutide (Eli Lilly), an injectable once-weekly combination GLP-1 receptor agonist, glucose-dependent insulinotropic polypeptide (GIP) and glucagon receptor agonist

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Findings: RCTSURMOUNT-MAINTAIN - Tirzepatide for Maintenance of Bodyweight Reduction in Obesity, Lancet (2026) [PubMed abstract] Design: Randomized, placebo-controlled trial (N=378 | length = 112 weeks) in adults with obesity who completed 60 weeks of open-label tirzepatide at the maximum tolerated dose (10 or 15 mg once weekly) Treatment: Continue tirzepatide maximum tolerated dose (MTD