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[ Randomized controlled trial, limited recommendation ] Key question Is combining GLP-1 RAs with basal insulin more effective than continuing monotherapy (either GLP-1 RA alone or basal insulin alone) in people who did not achieve their glycemic target with monotherapy

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Before GLP-1s, medicines that targeted inflammation like steroids worked by shutting it down, suppressing the immune system and making patients more vulnerable to infections and cancer

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doi: 10.1080/14656566.2024.2343092