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Indeed, these combinations provide a preferable alternative than simply increasing the insulin dose in subjects already exhibiting suboptimal glycemic responses to insulin [93,94] or those exhibiting insufficient responses to GLP-1R agonist therapy [95,96]

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M., Alizadeh, M., & Maleki, V

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Holistic recommendations for diet, exercise, and lifestyle modifications

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A 20-week study to observe the effects of exenatide plus rosiglitazone on -cell function and insulin sensitivity using hyperglycemic and euglycemic insulin clamp techniques in type 2 diabetes mellitus patients currently taking metformin has been conducted [28]

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That's where the "Ozempic-adjacent" framing comes from

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2024 May 7;8(1):777-789

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