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The majority of studies indicate that defective GLP-1 secretion does not appear to predate the development of glucose intolerance, rather diabetes itself seems to be associated with the acquired defect in GLP-1 secretion and GIP action [23]

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486,487,488 Notably, filgotinib has good oral availability, reaching maximum plasma concentrations at 13 h and plasma steady-state concentrations on day 2, making it a promising biologic agent for the treatment of UC

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