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2021A genetic map of the mouse dorsal vagal complex and its role in obesity

The majority of nausea, vomiting, and/or diarrhea events occurred during a dose increase and decreased over time

While Zepbound is not directly known to cause NAION, its effects on blood sugar and potential impacts on vascular health in diabetic patients could theoretically contribute to an increased risk

This significantly reduces the long-term risk of heart attack and stroke

But GLP-1 also has an indirect effect on the liver (by lowering hepatic gluconeogenesis) and the brain (by increasing neuroprotection) [56]

Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, et al