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The global impact of the GLP-1 revolution The France Info segment highlights a significant cultural moment: the conversation around obesity is shifting from blame and stigma to science and empathy

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Currently, the Wegovy pill (oral semaglutide 25mg) and orlistat are the oral weight loss medicines licensed in the UK

History of pancreatitis: If you have a history of pancreatitis, an inflammation of the pancreas, you should avoid GLP-1 medications as they can potentially increase the risk of this condition

This issue has been attributed to the mode of action of these antagonists: those blocking CAP-, proton-, and heat-induced TRPV1 activation result in hyperthermia, whereas those sparing proton-induced activation do not lead to hyperthermia 33,35

"People are taking these medications, and obviously there's a tremendous amount of upside," Horneff said