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The role of endogenous GLP-1 in heat sensitivity was demonstrated by the observation that the intraperitoneal glucose-treated group presented a decrease in heat sensitivity compared with the vehicle-treated group (Fig

Attenuated postprandial GLP-1 response in parkinsons disease

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American journal of physiology Heart and circulatory physiology

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The diabetes-induced reduction of neurogenesis in the hippocampal dentate implies a potential mechanism for diabetes-related cognitive decline.105110 A possible explanation is that pro-inflammatory factors in type 2 diabetes compromise endothelial caveolin-1, a major membrane intrinsic protein in the caveolae on the cell surface, leading to vascular dysfunction, affecting neurogenesis, and subsequently leading to AD.111 IKK/NF-B-mediated impairment112 and -aminobutyric acid and glutamate transporter systems113 may also be involved in diabetes-induced damage of neurogenesis