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Fatigue is listed as a common adverse reaction in the Summary of Product Characteristics for several GLP-1 medications, particularly at higher doses used for weight management

10.1016/j.neuro.2022.08.007 [DOI] [PubMed] [Google Scholar] 81.Jolivalt CG, Fineman M, Deacon CF, Carr RD, Calcutt NA (2011) GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice

For example, increased apoptosis induced by cellular stress leads to a loss of function and mass of pancreatic cells in T2DM

Endnotes These drugs are commonly prescribed for weight management, to treat type 2 diabetes, or to reduce the risk of heart attacks and stroke in people with cardiovascular disease

2 With the emergence of GLP-1 agonists, and their increased use to achieve glycemic control, exploring their potential advantages for patients with HS is warranted

All results were statistically significant except the heart failure finding