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The Difference Between Tapering and Continuous Maintenance Therapy Tapering typically means gradually reducing the dose or frequency of medication before stopping entirely

This results in a continuous energy deficit that drives weight loss

and that certainly there are groups of people for whom it should not be used

For women unable or unwilling to take HRT , several alternatives exist: Fezolinetant : a neurokinin-3 receptor antagonist specifically licensed for moderate to severe vasomotor symptoms, offering a non-hormonal option [19] [20] Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs): medications such as venlafaxine, citalopram, or fluoxetine may reduce hot flash frequency, though efficacy varies

28 Ex vivo slice [3H]DA transport assay The slices were obtained as described above and allowed to recover (1 h at 28 C) with continuous oxygenation

The groups were matched for age, sex and race