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These results indicate that expression screening is a useful system to identify GPCRs as targets of food components and strongly suggest that curcumin activates GPR55 as an agonist, which is involved in the physiological function of curcumin

Conversion of proglucagon in pancreatic alpha cells: the major endproducts are glucagon and a single peptide, the major proglucagon fragment, that contains two glucagon-like sequences

Previous studies in Zucker rats suggest that GIP signalling is muted during obesity [14]

24 Instead, it appears to be highly modifiable

Clinical trials show an average weight loss of around 21%

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