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GLP-1R are expressed in both glomeruli and renal tubules, suggesting a direct effect on kidney function

If storage beyond 30 days is necessary, aliquot the solution and freeze it at -20C to -80C to avoid freeze-thaw cycles that could degrade the peptide

Note: Each manufacturer has different instructions for how to administer an injection

Fetissov SO, Kopp J, Hkfelt T

Additionally, a single molecule tri-agonist of GLP-1R, GIPR and GCGR can increase insulin secretion and improve blood glucose handling in mice beyond the cumulative effects of the three individual agonists separately (Khajavi et al., 2018)

The bifurcation is already underway