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Initial small trials from 2016 to 2017, including EXSCEL, FIGHT, and LIVE, were not supportive of the use of GLP-1RAs in HFrEF with negative outcomes related to cardiovascular events [53,54,55]

Mint, citrus, or cinnamon flavours are often helpful

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Preclinical studies in animal models have demonstrated neuroprotective effects of GLP-1 receptor agonists

Research has not demonstrated significant differences in efficacy between morning and evening administration for once-daily or once-weekly formulations, provided the medication is taken regularly

Very impressive turnaround