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Susan Li, a healthcare policy expert

It also induces nitric oxidemediated vasodilation and thus may have implications for CV disease (37, 68) and kidneys

Interestingly, liraglutide showed the highest FAERS reporting odds ratio for thyroid cancer (15.59) among GLP-1 agonists, yet long-term population studies have not confirmed increased thyroid cancer risk with liraglutide either

They are found in the pancreas (where they regulate insulin secretion), the stomach (where they slow gastric emptying), the brain (where they influence appetite and satiety), and the cardiovascular system (where they affect heart rate and blood pressure)

For women with PCOS or insulin resistance, weight loss and metabolic improvements can also lead to better mood and increased body confidence over time

Whilst sleep disturbances may occur indirectly through gastrointestinal symptoms, metabolic changes, or lifestyle adjustments during treatment, no direct causal link between tirzepatide and primary insomnia has been established