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Daniel, J.D

Their analysis shows that excluding GLP-1 assets from the model would reduce the average IRR from 5.9% to just 3.8%, highlighting their outsized impact on industry performance

3.1.2 Exenatide As the first GLP-1R agonist approved for T2DM, EX is a new class of compound and a synthetic product of exendin-4, which is a compound naturally derived from the Gila monster and has multiple hypoglycemic mechanisms: inhibiting of glucagon release from cells, slowing of gastric emptying, decreasing appetite and increasing glucose-dependent insulin secretion (12, 46, 47)

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GLP-1R-evoked pericyte relaxation is via activation of K ATP channels To investigate the mechanism by which GLP-1 receptor activation protects against the ischaemia/reperfusion-induced pericyte contraction 8,12 that blocks capillaries and reduces coronary blood flow, we used an ex vivo preparation