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According to the Faculty of Sexual and Reproductive Healthcare, tirzepatide can reduce exposure to oral contraceptives, and additional barrier methods or alternative contraception are recommended for 4 weeks after initiation and each dose increase

Other GLP-1-adjacent entrants are at similar stages: plausible biology, modest early signals, and RCTs in flight

Raising awareness about this newly identified risk provides an opportunity to develop medication safety strategies and prevent patient harm

They're also available in oral supplement form , although this is less widely known

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