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Description
Hormonal status influences insulin sensitivity, and insulin sensitivity strongly affects how the body responds to GLP-1 medications

doi: 10.1111/j.1432-1033.1994.1151b.x 45 GallwitzBWittMMorys-WortmannCFlschURSchmidtWE

If you suspect you have experienced an adverse reaction to a GLP-1 receptor agonist, including gallbladder problems, you can report this through the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)
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As body fat decreases, estrogen levels may shift (less aromatase activity), and HRT dosing may need adjustment

It could be significant

It is also important to note that most of these studies focus on short-term effects that may not hold up with extended use
