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GLP-1 medications could transform the management of male infertility if subsequent studies confirm these early findings

GIP-1 Tirzepatide treatment Tirzepatide is an acylated peptide engineered to activate the GIP and GLP-1 receptors, key mediators of insulin secretion that are also expressed in regions of the brain that regulate food intake
Whats more, a recent retrospective, multicenter cohort study denied higher occurrence of nonarteritic anterior ischemic optic neuropathy (NAION) in GLP-1RAs users and suggested that its potential benefits for blood glucose control and cardiovascular health likely outweigh its risks (Chou et al., 2025), despite that a few research have reported association between semaglutide prescription and a higher risk of NAION(61)

During the double-blind period, 60.3% of participants continuing tirzepatide reported at least 1 treatment-emergent adverse event compared with 55.8% of participants who switched to placebo (Table 3)
